Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort

• Published in: Metabolites 2019-09, Vol.9 (9), p.190
• Main Authors: Taylor, Kurt, Ferreira, Diana L Santos, West, Jane, Yang, Tiffany, Caputo, Massimo, Lawlor, Deborah A
• Format: Article
• Language: English
• Subjects: Age; Amino acids; Apolipoproteins; birth cohort; Body fat; Body mass index; Born in Bradford; cardiometabolic profile; Cardiovascular disease; Cholesterol; Creatinine; Cultural differences; Diabetes mellitus; ethnicity; Fatty acids; Gestation; Gestational diabetes; Glucose; Hypertension; Insulin; Linoleic acid; Lipoproteins; Metabolism; Metabolites; Metabolomics; Minority & ethnic groups; NMR; Nuclear magnetic resonance; Phospholipids; Polyunsaturated fatty acids; Pre-eclampsia; Preeclampsia; Pregnancy; serum; Skinfold thickness; Triglycerides; Women
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo9090190

There is widespread metabolic disruption in women upon becoming pregnant. South Asians (SA) compared to White Europeans (WE) have more fat mass and are more insulin-resistant at a given body mass index (BMI). Whether these are reflected in other gestational metabolomic differences is unclear. Our aim was to compare gestational metabolic profiles and their determinants between WE and SA women. We used data from a United Kingdom (UK) cohort to compare metabolic profiles and associations of maternal age, education, parity, height, BMI, tricep skinfold thickness, gestational diabetes (GD), pre-eclampsia, and gestational hypertension with 156 metabolic measurements in WE ( = 4072) and SA ( = 4702) women. Metabolic profiles, measured in fasting serum taken between 26-28 weeks gestation, were quantified by nuclear magnetic resonance. Distributions of most metabolic measures differed by ethnicity. WE women had higher levels of most lipoprotein subclasses, cholesterol, glycerides and phospholipids, monosaturated fatty acids, and creatinine but lower levels of glucose, linoleic acid, omega-6 and polyunsaturated fatty acids, and most amino acids. Higher BMI and having GD were associated with higher levels of several lipoprotein subclasses, triglycerides, and other metabolites, mostly with stronger associations in WEs. We have shown differences in gestational metabolic profiles between WE and SA women and demonstrated that associations of exposures with these metabolites differ by ethnicity.