Blood feeding tsetse flies as hosts and vectors of mammals-pre-adapted African Trypanosoma: current and expected research directions

Research on the zoo-anthropophilic blood feeding tsetse flies' biology conducted, by different teams, in laboratory settings and at the level of the ecosystems- where also co-perpetuate African Trypanosoma- has allowed to unveil and characterize key features of tsetse flies' bacterial symb...

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Bibliographic Details
Published in:BMC microbiology 2018-11, Vol.18 (Suppl 1), p.162-162, Article 162
Main Authors: Geiger, Anne, Malele, Imna, Abd-Alla, Adly M, Njiokou, Flobert
Format: Article
Language:English
Subjects:
African trypanosomiasis
Animals
Bacteria
Bacteriome
Blood
Control
Ecosystem
Ecosystems
Feeding
Feeding Behavior
Flies
Genes
Genomes
Genomics
Infections
Insect Vectors - microbiology
Laboratories
Mammals - parasitology
Microbiota
Muscidae
Parasites
Parasitic diseases
Prevention
Review
Symbionts
Symbiosis
Trends
Tropical diseases
Trypanosoma
Trypanosoma - physiology
Trypanosomes
Trypanosomiasis, African - prevention & control
Trypanosomiasis, African - transmission
Tsetse flies
Tsetse Flies - parasitology
Tsetse Flies - physiology
Vector control
Vectors
Vectors (Biology)
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Summary:Research on the zoo-anthropophilic blood feeding tsetse flies' biology conducted, by different teams, in laboratory settings and at the level of the ecosystems- where also co-perpetuate African Trypanosoma- has allowed to unveil and characterize key features of tsetse flies' bacterial symbionts on which rely both (a) the perpetuation of the tsetse fly populations and (b) the completion of the developmental program of the African Trypanosoma. Transcriptomic analyses have already provided much information on tsetse fly genes as well as on genes of the fly symbiotic partners Sodalis glossinidius and Wigglesworthia, which account for the successful onset or not of the African Trypanosoma developmental program. In parallel, identification of the non- symbiotic bacterial communities hosted in the tsetse fly gut has recently been initiated: are briefly introduced those bacteria genera and species common to tsetse flies collected from distinct ecosystems, that could be further studied as potential biologicals preventing the onset of the African Trypanosoma developmental program. Finally, future work will need to concentrate on how to render tsetse flies refractory, and the best means to disseminate them in the field in order to establish an overall refractory fly population.
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-018-1281-x