Current Knowledge of MicroRNAs (miRNAs) in Acute Coronary Syndrome (ACS): ST-Elevation Myocardial Infarction (STEMI)

Regardless of the newly diagnostic and therapeutic advances, coronary artery disease (CAD) and more explicitly, ST-elevation myocardial infarction (STEMI), remains one of the leading causes of morbidity and mortality worldwide. Thus, early and prompt diagnosis of cardiac dysfunction is pivotal in ST...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2021-10, Vol.11 (10), p.1057
Main Authors: Tanase, Daniela Maria, Gosav, Evelina Maria, Ouatu, Anca, Badescu, Minerva Codruta, Dima, Nicoleta, Ganceanu-Rusu, Ana Roxana, Popescu, Diana, Floria, Mariana, Rezus, Elena, Rezus, Ciprian
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute coronary syndromes
Biomarkers
Cardiovascular disease
Coronary artery
Coronary artery disease
Diagnostic systems
Heart diseases
microRNA
MicroRNAs
miR
miRNA
Morbidity
Myocardial infarction
Review
STEMI
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Summary:Regardless of the newly diagnostic and therapeutic advances, coronary artery disease (CAD) and more explicitly, ST-elevation myocardial infarction (STEMI), remains one of the leading causes of morbidity and mortality worldwide. Thus, early and prompt diagnosis of cardiac dysfunction is pivotal in STEMI patients for a better prognosis and outcome. In recent years, microRNAs (miRNAs) gained attention as potential biomarkers in myocardial infarction (MI) and acute coronary syndromes (ACS), as they have key roles in heart development, various cardiac processes, and act as indicators of cardiac damage. In this review, we describe the current available knowledge about cardiac miRNAs and their functions, and focus mainly on their potential use as novel circulating diagnostic and prognostic biomarkers in STEMI.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11101057