The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics

An effective and well-balanced immune system is pivotal for maintaining health. Diet and nutrition can affect the functioning of numerous immune parameters, with direct repercussions on homeostasis. Since our immune functions are indispensable in defending the body against pathogens and thus play a...

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Bibliographic Details
Published in:Pharmaceutics 2021-05, Vol.13 (5), p.666
Main Authors: Răducanu, Adina Elena, Tihăuan, Bianca-Maria, Marinaș, Ioana Cristina, Ciupercă, Oana Teodora, Țebrencu, Carmen Elena, Ionescu, Elena, Onisei, Tatiana
Format: Article
Language:English
Subjects:
antimicrobial
cytotoxic
Dietary minerals
Dietary supplements
Food products
Functional foods & nutraceuticals
Immune system
Ingredients
novel nutraceuticals
Nutrition
Physiology
Phytochemicals
plant-based immunomodulators
pre-probiotics
Prebiotics
Probiotics
Seeds
Vitamins
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Summary:An effective and well-balanced immune system is pivotal for maintaining health. Diet and nutrition can affect the functioning of numerous immune parameters, with direct repercussions on homeostasis. Since our immune functions are indispensable in defending the body against pathogens and thus play a vital role in maintaining health, modulating immune response may well serve as the basis for the development of plant-based functional foods and novel nutraceuticals. This concept is currently utilized in attempts to prevent or mitigate inflammatory reactions via the development of targeted food products or active ingredients since an extended number of phytoconstituents (such as curcuminoids) are associated with beneficial effects on immunity. Immunomodulatory plant-based dietary supplements are considered effective in improving immune functions and reducing the incidence of immunological disorders or imbalances. Therefore, the main focus of this study was to evidence the beneficial biological effects such as antioxidant and antimicrobial, as well as nutritional status, biocompatibility and cell proliferation capacity and immunomodulation of two novel nutraceuticals. The first nutraceutic was based on curcuminoids and other actives from Trigonella foenum- graecum (seeds), Chelidonium majus L. (aerial parts), Taraxacum officinale L. (roots), vitamins (C, D3, A, E) and minerals (zinc) whereas the second one was made of probiotics such as Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis combined with actives from Helianthus tuberosus (tubers) and Psyllium/Plantago ovata (husk) as herbal prebiotics.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13050666