HLA DRB1 polymorphism and risk of HIV/tuberculosis co-infection

• Published in: Medychni perspektyvy 2017-01, Vol.22 (3), p.81-88
• Main Authors: Shostakovych-Koretskaya, L R, Volikova, O O, Lytvyn, K Y, Gubar, I O, Kushnerova, O A, Sheveleva, O V
• Format: Article
• Language: eng ; rus ; ukr
• Subjects: Antiretroviral drugs; co-infection HIV/tuberculosis; Genetics; HIV; HIV-infected patients; HLA DRB1 gene polymorphism; Human genetics; Human health and pathology; Human immunodeficiency virus; Infections; Infectious diseases; Life Sciences; Polymorphism; Tuberculosis
• ISSN: 2307-0404
• DOI: 10.26641/2307-0404.2017.3.111930

In the research data on the study of interconnection between polymorphism of HLA DRB1 genes and the risk of HIV infection and co-infection and HIV/tuberculosis are presented.The cohort of observation was HIV-infected individuals with different clinical stages aged from 24 to 58 years, average age being 38 years. 90 patients (89.2%) received HAART.There were 32 (31.4%) HIV-infected patients with manifestations of tuberculosis, 70 (68.6%) HIV patients without manifestations of tu­ber­culosis. Among the cohort of HIV-infected patients with manifestations of tuberculosis, pulmonary forms of tuberculosis was in 32 (100%), of which extrapulmonary forms of tuberculosis were in 12 (37.5%) patients. The majority of cases of tuberculosis occurred in HIV-infected patients in the IV clinical stage. Among HIV-infected patients, the following alleles of the HLA gene DRB1 *01 (10%) *04 (10%) *07 (13%), *11 (15%), *13 (13%), *15 (10%) occurred more often, HLA DRB1 *03 *08 *09 *10, *12, *14, *16, * 17, *18 were rarely found (1-7%). Similar distributions of DRB1 genes were noted among residents of the region with the dominance of HLA DRB1 *01 *04 *07 *11 *13 and *15. With the presence of alleles of the locus DRB1 *13, DRB1 *03 and DRB1 *08, the greatest probability of co-infection of tuberculosis was observed in HIV-infected patients. The risk of tuberculosis is by 2 times higher with a significant difference in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 - by 4.4 times and DRB1 *08 - by 5.4 times. Significant chances of tuberculosis occurrence are higher - by 2.6 times in HIV-infected patients with DRB1 *13 locus alleles, DRB1 *03 - by 5.1 times and DRB1 *08 - by 6.4 times. Thus, the variability of the HLA DRB1 locus alleles may play a predisposing or protective role in the occurrence of tuberculosis in HIV-infected patients.