Structural hemodynamic valve deterioration durability of RESILIA-tissue versus contemporary aortic bioprostheses

Durability of aortic valve replacement is becoming increasingly important. Aortic bioprostheses with RESILIA tissue have demonstrated outstanding outcomes thus far, but only in single-arm studies. We compared structural valve deterioration (SVD)-related hemodynamic valve deterioration (HVD) of grade...

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Published in:Journal of comparative effectiveness research 2023-03, Vol.12 (3), p.e220180-e220180
Main Authors: Bartus, Krzysztof, Bavaria, Joseph E, Thourani, Vinod H, Xu, Ke, Keuffel, Eric L
Format: Article
Language:English
Subjects:
Aortic Valve - surgery
aortic valve replacement
Bioprosthesis
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
hemodynamic valve deterioration
Hemodynamics
Humans
INSPIRIS RESILIA aortic valve
RESILIA tissue
structural hemodynamic valve deterioration
Treatment Outcome
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Summary:Durability of aortic valve replacement is becoming increasingly important. Aortic bioprostheses with RESILIA tissue have demonstrated outstanding outcomes thus far, but only in single-arm studies. We compared structural valve deterioration (SVD)-related hemodynamic valve deterioration (HVD) of grade ≥2 of RESILIA tissue valves from the COMMENCE trial (n = 689) to those from the PARTNER 2A contemporary AVR arm (n = 936) based upon annual core laboratory echocardiograms through 5 years of follow-up. SVD-related HVD in the COMMENCE and PARTNER 2A cohorts were 1.8 versus 3.5%, respectively (one-sided 95% lower-bound hazard ratio of 0.92; p = 0.07). In propensity-matched cohorts (n = 239), these outcomes were 1.0 versus 4.8%, respectively (one-sided 95% lower-bound hazard ratio of 1.15; p = 0.03). RESILIA tissue-based AVR exhibited reduced SVD-related HVD compared with a contemporary AVR cohort devoid of RESILIA tissue.
ISSN:2042-6305
2042-6313
DOI:10.2217/cer-2022-0180