Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis

• Published in: Saudi journal of gastroenterology 2016-09, Vol.22 (5), p.375-379
• Main Authors: Kozlowska, Joanna, Mikula, Tomasz, Suchacz, Magdalena, Jabnonska, Joanna, Stanczak, Wojciech, Cianciara, Janusz, Wiercinska-Drapalo, Alicja
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol; Angiogenesis; Apoptosis; Biomarkers - blood; Cancer; Carcinoma, Hepatocellular - diagnosis; Complications and side effects; Development and progression; Disease Progression; Early Detection of Cancer; Enzymes; Extracellular matrix; Eye Proteins - blood; Female; Fibrosis markers; Genetic aspects; Glycoproteins; Hepatitis; Hepatocellular carcinoma; Humans; Liver cirrhosis; Liver Cirrhosis - metabolism; Liver diseases; Liver Neoplasms - diagnosis; Male; Matrix Metalloproteinase 9 - blood; Metalloenzymes; Metastasis; Middle Aged; Molecular weight; Nerve Growth Factors - blood; Original; Patients; Physiological aspects; Risk factors; Serpins - blood; Studies
• ISSN: 1319-3767; 1998-4049
• DOI: 10.4103/1319-3767.191143

Background/Aim: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). Patients and Methods: Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group of 30 healthy volunteers. HCC was diagnosed in 45 of the 212 patients studied (21%). Results: Serum PEDF and MMP-9 were higher in the study group than that in the control group (P < 0.001). In patients with alcoholic or mixed (alcoholic and viral hepatitis-related) cirrhosis, serum PEDF was higher than that in other patients (13970.2 ± 13406.9 ng/ml vs. 8563.5 ± 9602.7 ng/ml, P = 0.008). In patients with viral hepatitis-related cirrhosis, significantly higher PEDF levels were recorded in those with HCC (13429.1 ± 12045.8) than that in patients without HCC (6660.1 ± 7927.1; P = 0.04). There was a trend for higher serum MMP-9 in patients with HCC (5778.7 ± 12426.6 vs. 1389.8 ± 1944.7 in those without HCC; P = 0.07). Significant negative correlation between serum MMP-9 and serum alpha-fetoprotein in patients with HCC was observed (r = −0.54; P = 0.04). Conclusion: Serum PEDF and MMP-9 could be auxiliary markers in diagnosis of HCC, especially in patients with low alpha-fetoprotein level. Alcohol consumption can affect serum PEDF.