Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix

•NTRK rearranged spindle cell neoplasms of the lower female genital tract are an emerging entity.•Characteristic histomorphological changes can give hints for the correct diagnosis.•We present a case where a fertility preserving local surgical treatment was performed. In depth molecular studies are...

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Bibliographic Details
Published in:Gynecologic oncology reports 2023-08, Vol.48, p.101233, Article 101233
Main Authors: Bühler, Marco M., Honcharova-Biletska, Hanna, Pauli, Chantal, Chronas, Dimitrios, Bolten, Kristina
Format: Article
Language:English
Subjects:
Cervical sarcoma
Conservative surgery
NTRK fusion
NTRK rearranged tumor
Survey
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Summary:•NTRK rearranged spindle cell neoplasms of the lower female genital tract are an emerging entity.•Characteristic histomorphological changes can give hints for the correct diagnosis.•We present a case where a fertility preserving local surgical treatment was performed. In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase inhibitors. Nonetheless, surgery remains the initial treatment of choice. We present the case of a 24-year-old patient suffering from a NTRK rearranged spindle cell neoplasm of the uterine cervix which was treated with a fertility preserving conservative surgical approach.
ISSN:2352-5789
2352-5789
DOI:10.1016/j.gore.2023.101233