Sub-acute administration of lower doses of nicotine caused sex-dependent improvement of renal function in Wistar rats

The adverse and beneficial health effects of nicotine (NIC), the major alkaloid found in cigarettes and tobacco, are controversial. Most studies on NIC have focused on its effects on cardiovascular and nervous functions. This study aimed at determining dose- and sex-specific effects of sub-acute (28...

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Published in:Toxicology reports 2017-01, Vol.4, p.535-542
Main Authors: Akomolafe, Ojo Rufus, Imafidon, Christian Eseigbe, Olukiran, Olaoluwa Sesan, Oladele, Ayowole Abraham, Akanji, Babatunde Oludare
Format: Article
Language:English
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Summary:The adverse and beneficial health effects of nicotine (NIC), the major alkaloid found in cigarettes and tobacco, are controversial. Most studies on NIC have focused on its effects on cardiovascular and nervous functions. This study aimed at determining dose- and sex-specific effects of sub-acute (28 days) NIC administration on some indices of kidney function in Wistar rats. Forty rats (20 males and 20 females), 8-9 weeks old (each housed in separate metabolic cage), were used for this study such that graded doses of NIC (1, 2 and 4 mg/kg i.p. for 28 days) were administered to both sexes while each control received distilled water at 0.2 mL/100 g i.p. Blood was collected under ketamine anesthesia (10 mg/kg i.m) for analyses and results obtained were compared at p 
ISSN:2214-7500
2214-7500
DOI:10.1016/j.toxrep.2017.10.001