Establishment of a new human iPSC cell line (UOMi012-A) from a patient with congenital heart defect who has undergone Fontan procedure

Patients born with complex congenital heart defects, not amenable for surgical repair establishing normal bi-ventricular circulation are palliated with the Fontan Circulation (FC). Here, we report new iPSC line from a patient with tricuspid and pulmonary atresia. The patient underwent series of surg...

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Bibliographic Details
Published in:Stem cell research 2024-10, Vol.80, p.103509, Article 103509
Main Authors: Sareen, Niketa, Srivastava, Abhay, Mittal, Ishika, Shah, Ashish H., Dhingra, Sanjiv
Format: Article
Language:English
Subjects:
Adult
Cell Differentiation
Cell Line
Female
Fontan Procedure
Heart Defects, Congenital - pathology
Heart Defects, Congenital - surgery
Humans
Induced Pluripotent Stem Cells
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Summary:Patients born with complex congenital heart defects, not amenable for surgical repair establishing normal bi-ventricular circulation are palliated with the Fontan Circulation (FC). Here, we report new iPSC line from a patient with tricuspid and pulmonary atresia. The patient underwent series of surgeries leading to completion of Fontan circulation at the age of 13yr., and this line was generated when she was 38yr. old. The exact genetic cause of this patient’s congenital heart defect is unknown, and this line will be used for studying molecular and cellular mechanisms responsible for cardiac dysfunction, along with screening for future potential therapeutic avenues.
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103509