Multiple drug resistant urinary tract infection in kidney transplant recipients : a retrospective cohort study

Urinary tract infection (UTI) is the most common infectious disease in post-kidney transplantation patients. The objective of the study was to investigate the prevalence, impact and risk factors of multiple drug resistant (MDR) UTI in kidney transplant recipients. This retrospective cohort study rec...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2020-09, Vol.31 (5), p.905-916
Main Authors: Lal, Naranjan, Ibn Hamid, Rashid, Javaid, Shanila, Khan, Muhammad Tasadduq, Luxmi, Shubha, Sarfaraz, Sabahat
Format: Article
Language:English
Subjects:
Analysis
Cohort analysis
Communicable diseases
Drug resistance
E coli
Health aspects
Intubation
Kidney transplantation
Kidney transplants
Medical research
Pathogens
Risk factors
Tazobactam
Urinary tract diseases
Urinary tract infections
Urogenital system
Valganciclovir
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Summary:Urinary tract infection (UTI) is the most common infectious disease in post-kidney transplantation patients. The objective of the study was to investigate the prevalence, impact and risk factors of multiple drug resistant (MDR) UTI in kidney transplant recipients. This retrospective cohort study recruited 72 kidney transplant recipients between March 2017 and February 2018. Urine cultures performed during the 1st year of posttransplantation with reference to clinical data were evaluated. Predesigned questionnaire was used to collect data regarding demographic, transplant related, and microbiological information. Multivariate analysis was performed to ascertain risk factors of MDR UTI. Out of 72 patients, 28 (38.9%) had culture guided clinical UTI. Overall, 59 UTI episodes were noted throughout the duration of this study. Eschericia coli were found to be the most frequent uropathogen of UTI among kidney transplant recipients (n = 32, 54.2%). MDR bacteria were responsible for 27.1% (n = 16) of the post-transplantation UTI episodes among patients, with E. coli (n = 9, 56.3%) being the predominant bacterial pathogen. Most of the MDR strains of E. coli (n = 7, 77.8%) were extended spectrum beta-lactamase positive. Female gender (P
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.301197