Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation

Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examined whether ethanol extracts of (Lour.) Baill. (SE)...

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Published in:International journal of molecular sciences 2022-05, Vol.23 (10), p.5757
Main Authors: Hayashi, Kenjiro, Sato, Koichi, Ochi, Seishi, Kawano, Shuhei, Munesue, Seiichi, Harashima, Ai, Oshima, Yu, Kimura, Kumi, Kyoi, Takashi, Yamamoto, Yasuhiko
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Atherosclerosis
Bovine serum albumin
Competition
Diabetes
Diabetes mellitus
Drug dosages
Ethanol
Glucose
Glycosylation
Inflammation
Ligands
Lipopolysaccharides
Macrophages
NF-κB protein
Plasma
Rats
receptor for advanced glycation end-products (RAGE)
Rodents
Saururus chinensis
Saururus chinensis (Lour.) Baill
Serum albumin
Streptozocin
Tumor necrosis factor-TNF
Tumor necrosis factor-α
vascular relaxation
Vasodilation
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Summary:Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes. Signaling pathways downstream of RAGE are involved in NF-κB activation. In this study, we examined whether ethanol extracts of (Lour.) Baill. (SE) could affect RAGE signaling and vascular relaxation in streptozotocin (STZ)-induced diabetic rats. Treatment with SE inhibited AGEs-modified bovine serum albumin (AGEs-BSA)-elicited activation of NF-κB and could compete with AGEs-BSA binding to RAGE in a dose-dependent manner. Tumor necrosis factor-α (TNF-α) secretion induced by lipopolysaccharide (LPS)-a RAGE ligand-was also reduced by SE treatment in wild-type mice as well as in cultured peritoneal macrophages from mice but not in mice. SE administration significantly ameliorated diabetes-related dysregulation of acetylcholine-mediated vascular relaxation in STZ-induced diabetic rats. These results suggest that SE would inhibit RAGE signaling and would be useful for the improvement of vascular endothelial dysfunction in diabetes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23105757