Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges

What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burden diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-11, Vol.26 (22), p.7022
Main Authors: Oliveira, Filipe, Santos, Filipa, Duarte, Ana Rita C.
Format: Article
Language:English
Subjects:
Acids
active pharmaceutical ingredient
Anti-inflammatory agents
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Biological activity
Cancer
Chemical bonds
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
drug delivery
Drug resistance
Drugs
Epidemics
Eutectic composition
Green chemistry
Hydrogen bonding
Hydrogen bonds
Inflammation
Investigations
Melt temperature
Metastases
Microbial activity
Microorganisms
Multidrug resistance
New technology
Pharmaceutical industry
Pharmaceutical sciences
Pharmaceuticals
R&D
Research & development
Review
Severe acute respiratory syndrome coronavirus 2
Solvents
therapeutic deep eutectic systems
Tuberculosis
Tumors
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Summary:What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burden diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which results a melting temperature depression in comparison with that of its individual components. Therapeutic deep eutectic systems are defined as eutectic systems in which at least one of the individual components is an active pharmaceutical ingredient, or a eutectic system in which the active pharmaceutical ingredient is dissolved. Current literature reports on tuberculosis have been mostly based on the most common anti-tuberculosis drugs prescribed. Using eutectic systems based on naturally occurring molecules known for their anti-microbial activity may also present a promising therapeutic strategy able to cope with the prevalence of Mycobacterium tuberculosis and prevent the appearance of multidrug resistance strains. With regards to colorectal cancer, literature has been unravelling combinations of terpenes with anti-inflammatory drugs that are selectively cytotoxic towards colorectal cancer cells and do not compromise the viability of normal intestinal cells. This technology could contribute to preventing tumor growth and metastasis while providing a patient compliance therapeutics, which will be crucial to the success of overcoming the challenges presented by cancers.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26227022