Mobilization of peripheral blood stem cells in myeloma with either pegfilgrastim or filgrastim following chemotherapy

1 Division of Hematology and Blood and Bone Marrow Transplantation, University of Utah School of Medicine, Salt Lake City, UT 2 The Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 3 The Cancer Research and Biostatistics, Seattle, WA and 4 Depa...

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Bibliographic Details
Published in:Haematologica (Roma) 2008-11, Vol.93 (11), p.1739-1742
Main Authors: Tricot, Guido, Barlogie, Bart, Zangari, Maurizio, van Rhee, Frits, Hoering, Antje, Szymonifka, Jackie, Cottler-Fox, Michele
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents, Alkylating - therapeutic use
Biological and medical sciences
Combined Modality Therapy
Dose-Response Relationship, Drug
Filgrastim
Granulocyte Colony-Stimulating Factor - therapeutic use
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Mobilization - methods
Hematopoietic Stem Cell Transplantation - methods
Hemoglobins - metabolism
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Melphalan - therapeutic use
Middle Aged
Multiple Myeloma - drug therapy
Multiple Myeloma - surgery
Platelet Count
Polyethylene Glycols
Recombinant Proteins
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Summary:1 Division of Hematology and Blood and Bone Marrow Transplantation, University of Utah School of Medicine, Salt Lake City, UT 2 The Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 3 The Cancer Research and Biostatistics, Seattle, WA and 4 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Correspondence: Guido Tricot, MD, PhD, The University of Utah School of Medicine, 30N 1900E, 5C402,Salt Lake City, UT 84132 USA. E-mail: guido.tricot{at}hsc.utah.edu ABSTRACT Quality and quantity of mobilized peripheral blood stem cells determine the safety of tandem autologous transplants in myeloma. Using the same mobilization chemotherapy with DT-PACE in two consecutive protocols, robustness of stem cell collection and rapidity of engraftment after transplantation were assessed. We employed either twice a day filgrastim versus two doses of pegfilgrastim. Advantages of pegfilgrastim were: (i) a higher percentage of patients collected 15 x 10 6 /kg in the first three days ( p
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.13204