Synaptic zinc potentiates AMPA receptor function in mouse auditory cortex

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical synaptic microcircuits and their functional specificity. To understand the role of zinc signaling in the cortex,...

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Bibliographic Details
Published in:Cell reports (Cambridge) 2023-08, Vol.42 (8), p.112932-112932, Article 112932
Main Authors: Bender, Philip T.R., McCollum, Mason, Boyd-Pratt, Helen, Mendelson, Benjamin Z., Anderson, Charles T.
Format: Article
Language:English
Subjects:
AMPA receptors
auditory cortex
corticocallosal neurons
corticocollicular neurons
CP: Neuroscience
glutamate
NMDA receptors
Slc30a3
synaptic transmission
synaptic zinc
ZnT3
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Summary:Synaptic zinc signaling modulates synaptic activity and is present in specific populations of cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical synaptic microcircuits and their functional specificity. To understand the role of zinc signaling in the cortex, we performed whole-cell patch-clamp recordings from intratelencephalic (IT)-type neurons and pyramidal tract (PT)-type neurons in layer 5 of the mouse auditory cortex during optogenetic stimulation of specific classes of presynaptic neurons. Our results show that synaptic zinc potentiates AMPA receptor (AMPAR) function in a synapse-specific manner. We performed in vivo 2-photon calcium imaging of the same classes of neurons in awake mice and found that changes in synaptic zinc can widen or sharpen the sound-frequency tuning bandwidth of IT-type neurons but only widen the tuning bandwidth of PT-type neurons. These results provide evidence for synapse- and cell-type-specific actions of synaptic zinc in the cortex. [Display omitted] •Synaptic zinc potentiates AMPAR function in the auditory cortex•The effects of synaptic zinc on AMPAR function are cell-type and synapse specific•Synaptic zinc can enhance or suppress AMPAR function•Synaptic zinc can sharpen or broaden sound-frequency tuning bandwidths of layer 5 neurons Bender et al. provide evidence that synaptically released zinc potentiates AMPAR function in a synapse-specific manner, and that this potentiation can be enhanced or suppressed in a zinc concentration-dependent manner. These findings unify opposing reports of the function of synaptic zinc signaling.
ISSN:2211-1247
2211-1247
DOI:10.1016/j.celrep.2023.112932