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HP-CagA+ Regulates the Expression of CDK4/CyclinD1 via reg3 to Change Cell Cycle and Promote Cell Proliferation
Previous studies have shown that regeneration gene 3 ( ) is significantly expressed in gastric mucosa tissues with (HP) cytotoxin-associated gene A (CagA)-positive (HP-CagA+). CagA-positive HP increases the risk of gastric cancer. The purpose of this study was to investigate the correlation between...
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Published in: | International journal of molecular sciences 2019-12, Vol.21 (1), p.224 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Previous studies have shown that regeneration gene 3 (
) is significantly expressed in gastric mucosa tissues with
(HP) cytotoxin-associated gene A (CagA)-positive (HP-CagA+). CagA-positive HP increases the risk of gastric cancer. The purpose of this study was to investigate the correlation between
and HP-CagA+ and explore the effects of
on the proliferation of gastric cancer cells and the development of tissues and organs. We analyzed the expression of reg3 in human tissues and organs. The results showed that
expression in gastric tissues was significantly higher than that in other tissues and organs. In addition,
influenced the prognosis of gastric, lung, and ovarian cancers. Immunohistochemical analysis indicated that the expression of
and CagA in cancerous tissues was higher than that in adjacent tissues. HP-CagA
infection of gastric cancer cells promotes reg3 expression, suggesting that
may be a target gene of CagA in gastric cancer, which together affects the formation and development of gastric cancer.
and CagA promote cell proliferation, and then affect the development of mouse tissues and organs by regulating G1/S phase transition of the cell cycle via the formation of the cell cycle-dependent complex CDK4/CyclinD1. This is the first study that shows the influence of CagA on the cell cycle and induction of cell proliferation by promoting
expression. |
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ISSN: | 1422-0067 1661-6596 1422-0067 |
DOI: | 10.3390/ijms21010224 |