An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients

The global elderly population is on the rise, and infections tend to have a higher mortality rate among older individuals. Aging is associated with the progressive impairment of multi-organ function, which can impact the pharmacokinetics of antimicrobials, potentially leading to the failure of anti-...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-09, Vol.15, p.1396994
Main Authors: Fu, Guanshuang, Sun, Weijia, Tan, Zhaoyi, Liang, Beibei, Cai, Yun
Format: Article
Language:English
Subjects:
anti-infective therapy
antimicrobial agents
drug resistance
elderly
pharmacokinetics
Pharmacology
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Summary:The global elderly population is on the rise, and infections tend to have a higher mortality rate among older individuals. Aging is associated with the progressive impairment of multi-organ function, which can impact the pharmacokinetics of antimicrobials, potentially leading to the failure of anti-infective therapy. With the increasing life expectancy, a significant growth in the elderly demographic, and the escalating costs of healthcare, gaining a thorough understanding of pharmacokinetic changes in the elderly holds crucial clinical significance. This review compiles findings from published studies, offering a comprehensive overview of the pharmacokinetics of various antimicrobials in both adults and the elderly. Furthermore, it delves into advancements in pharmacokinetic methods specific to the elderly population.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1396994