Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects

Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can change the translational profile of the recipient cell and modulate cellular morphology. This endogenous mechanism has...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-10, Vol.9 (10), p.2271
Main Authors: Munir, Javaria, Yoon, Jeong Kyo, Ryu, Seongho
Format: Article
Language:English
Subjects:
Biosynthesis
Body fluids
Cytology
diseases
drug-delivery
Engineering
Extracellular vesicles
Health aspects
Lipids
Mechanical properties
MicroRNA
miRNA
Organelles
Proteins
Review
therapy
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Summary:Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can change the translational profile of the recipient cell and modulate cellular morphology. This endogenous mechanism has attracted the attention of the drug-delivery community in the last few years. EVs can be enriched with exogenous therapeutic miRNAs and used for treatment of diseases by targeting pathological recipient cells. However, there are some obstacles that need to be addressed before introducing therapeutic miRNA-enriched EVs in clinics. Here, we focused on the progress in the field of therapeutic miRNA enriched EVs, highlighted important areas where research is needed, and discussed the potential to use them as therapeutic miRNA carriers in the future.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9102271