Loading…

Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias

Introduction Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later‐life dementia has not been fully explored. Methods Using the Utah Population Database, we performed an 80‐year retrospective cohort study of 5...

Full description

Saved in:
Bibliographic Details
Published in:Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2023-04, Vol.15 (2), p.e12443-n/a
Main Authors: Schliep, Karen C., Shaaban, C. Elizabeth, Meeks, Huong, Fraser, Alison, Smith, Ken R., Majersik, Jennifer J., Foster, Norman L., Wactawski‐Wende, Jean, Østbye, Truls, Tschanz, JoAnn, Padbury, James F., Sharma, Surrendra, Zhang, Yue, Facelli, Julio C., Abdelrahman, C. Samir, Theilen, Lauren, Varner, Michael W.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later‐life dementia has not been fully explored. Methods Using the Utah Population Database, we performed an 80‐year retrospective cohort study of 59,668 parous women. Results Women with, versus without, HDP, had a 1.37 higher risk of all‐cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid‐life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk. Discussion Improved HDP and mid‐life care could reduce the risk of dementia.
ISSN:2352-8729
2352-8729
DOI:10.1002/dad2.12443