Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity

Thrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain. TMA is a pathological feature of a number of...

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Bibliographic Details
Published in:JIM - high impact case reports 2017-07, Vol.5 (3), p.2324709617732797-2324709617732797
Main Authors: Chugh, Savneek, Kichloo, Asim, Jafri, Firas, Yusvirazi, Liga, Lerner, Robert
Format: Article
Language:English
Subjects:
Case Report
Case reports
Health risk assessment
Kidneys
Multiple myeloma
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Summary:Thrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain. TMA is a pathological feature of a number of clinical disorders including thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and atypical hemolytic uremic syndrome. Rare but important, TMA may also occur in malignancy, connective tissue disease, malignant hypertension, and renal transplantation (rejection or drug toxicity). We present a very rare case where the patient developed acute kidney injury from TMA but found to have multiple myeloma as the possible underlying etiology.
ISSN:2324-7096
2324-7096
DOI:10.1177/2324709617732797