The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology

• Published in: Journal of cardiovascular magnetic resonance 2019-11, Vol.21 (1), p.73-73, Article 73
• Main Authors: Nickander, Jannike, Themudo, Raquel, Thalén, Simon, Sigfridsson, Andreas, Xue, Hui, Kellman, Peter, Ugander, Martin
• Format: Article
• Language: English
• Subjects: Adenosine; Adenosine - administration & dosage; Adult; Blood; Blood Flow Velocity; Blood Volume; Cardiovascular disease; Cardiovascular diseases; Change detection; Contrast agents; Coronary artery disease; Coronary Circulation; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiology; Drug delivery systems; Edema; Extracellular volume; Female; Females; Gadobutrol; Healthy Volunteers; Heart attacks; Heart diseases; Heart rate; Humans; Image processing; Intravenous administration; Ischemia; Magnetic resonance; Magnetic Resonance Imaging, Cine; Male; Mapping; Medicin och hälsovetenskap; Myocardial blood volume; Myocardial ischemia; Myocardial Perfusion Imaging - methods; Myocardium; Native T1; Native T2; Perfusion; Physiological aspects; Physiology; Predictive Value of Tests; Quantitative perfusion; Regression analysis; Rest; Stress; Stress (Physiology); Stress cardiovascular magnetic resonance; Vasodilator Agents - administration & dosage; Young Adult
• ISSN: 1097-6647; 1532-429X; 1532-429X
• DOI: 10.1186/s12968-019-0585-9

Both ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosine stress without the use of contrast agents. Furthermore, native T2 mapping could also potentially be used to quantify changes in myocardial perfusion and/or MBV. Therefore, the aim of this study was to explore the relative contributions of myocardial perfusion, MBV and ECV to native T1 and native T2 at rest and during adenosine stress in normal physiology. Healthy subjects (n = 41, 26 ± 5 years, 51% females) underwent 1.5 T cardiovascular magnetic resonance (CMR) scanning. Quantitative myocardial perfusion [ml/min/g] and MBV [%] maps were computed from first pass perfusion imaging at adenosine stress (140 microg/kg/min infusion) and rest following an intravenous contrast bolus (0.05 mmol/kg, gadobutrol). Native T1 and T2 maps were acquired before and during adenosine stress. T1 maps at rest and stress were also acquired following a 0.2 mmol/kg cumulative intravenous contrast dose, rendering rest and stress ECV maps [%]. Myocardial T1, T2, perfusion, MBV and ECV values were measured by delineating a region of interest in the midmural third of the myocardium. During adenosine stress, there was an increase in myocardial native T1, native T2, perfusion, MBV, and ECV (p ≤ 0.001 for all). Myocardial perfusion, MBV and ECV all correlated with both native T1 and native T2, respectively (R  = 0.35 to 0.61, p