Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients

Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients w...

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Bibliographic Details
Published in:Kidney & blood pressure research 2014-01, Vol.39 (4), p.299-307
Main Authors: Ishimura, Eiji, Okuno, Senji, Okazaki, Hisanori, Norimine, Kyoko, Yamakawa, Kenjiro, Yamakawa, Tomoyuki, Shoji, Shigeichi, Nishizawa, Yoshiki, Inaba, Masaaki
Format: Article
Language:English
Subjects:
Aged
Alkaline Phosphatase - blood
Angiography
Bone formation markers
Bone Resorption - blood
Bone Resorption - enzymology
Bone resorption markers
Bone-specific alkaline phosphatase
Collagen Type I - blood
Diabetic Nephropathies - complications
Diabetic Nephropathies - therapy
Hand - blood supply
Hand - diagnostic imaging
Hemodialysis
Humans
Male
Middle Aged
Original Paper
Osteocalcin - blood
Osteogenesis
Parathyroid Hormone - blood
Regional Blood Flow
Renal Dialysis - adverse effects
Vascular calcification
Vascular Calcification - blood
Vascular Calcification - diagnostic imaging
Vascular Calcification - enzymology
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Summary:Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37 patients. Among the bone formation and resorption markers, serum BAP was significantly higher in patients with vascular calcification than in those without (p
ISSN:1420-4096
1423-0143
DOI:10.1159/000355807