Isolation and morphology of circulating tumor cells by cell block technique in breast cancer

Background: Circulating tumor cells (CTCs) are cells present in the blood stream that are antigenically or genetically similar to a specific tumor type and are markers of tumor diagnosis, prognosis, residual disease and metastasis. The ever-increasing burden of breast cancer globally warrants the in...

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Bibliographic Details
Published in:Indian journal of pathology & microbiology 2021-04, Vol.64 (2), p.329-333
Main Authors: Agrawal, Nandini, Punia, Rajpal, Handa, Uma, Attri, Ashok
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy
Biopsy, Fine-Needle - methods
Biopsy, Large-Core Needle - methods
Blood circulation
Breast cancer
Breast carcinoma
Breast Neoplasms - blood
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
cell block (cb)
Chemotherapy
circulating tumor cells (ctcs)
core needle biopsy (cnb)
Cytology
Female
fine-needle aspiration (fna)
Humans
Lymphatic Metastasis - pathology
Mammography
Markers
Metastases
Metastasis
Methods
Middle Aged
Morphology
Neoplastic Cells, Circulating - pathology
Peripheral blood
Prognosis
Prospective Studies
Tumor cells
Tumors
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Summary:Background: Circulating tumor cells (CTCs) are cells present in the blood stream that are antigenically or genetically similar to a specific tumor type and are markers of tumor diagnosis, prognosis, residual disease and metastasis. The ever-increasing burden of breast cancer globally warrants the incorporation of this all-inclusive marker in the diagnostic repertoire using the simplest of techniques. Aims: To identify CTCs in peripheral blood by cell block (CB) technique in cases of breast cancer diagnosed on fine-needle aspiration (FNA) or core needle biopsy (CNB) and to correlate their presence with nodal metastasis. Material and Methods: This study was conducted in the Department of Pathology, at a tertiary care hospital. Peripheral blood samples from a total of 30 cases of primary breast carcinoma diagnosed on FNA or CNB without prior neoadjuvant chemotherapy were analyzed using the CB technique. Results: The age ranged between 29-74 years with the most common presenting complaint being a palpable, single, unilateral breast lump. CTCs were detected in 2 (6.7%) cases with a
ISSN:0377-4929
0974-5130
DOI:10.4103/IJPM.IJPM_855_20