E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1

Long noncoding RNAs (lncRNAs) participate in biological processes in multiple types of tumors. However, the regulatory patterns of lncRNAs in prostate cancer remain largely unclear. Here, we evaluated the expression and roles of the lncRNA DLEU2 in prostate cancer. Our results showed that DLEU2 was...

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Bibliographic Details
Published in:Cell death & disease 2022-01, Vol.13 (1), p.77-77, Article 77
Main Authors: Li, Peizhang, Xu, Huan, Yang, Liu, Zhan, Ming, Shi, Yuanping, Zhang, Caoxu, Gao, Dajun, Gu, Meng, Chen, Yanbo, Wang, Zhong
Format: Article
Language:English
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Antibodies
Biochemistry
Biomedical and Life Sciences
Carcinogenesis - genetics
Cell Biology
Cell Culture
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
Cell Transformation, Neoplastic - genetics
E2F protein
E2F2 Transcription Factor - genetics
Gene Expression Regulation, Neoplastic
Glucocorticoids
Humans
Immediate-Early Proteins - metabolism
Immunology
Kinases
Life Sciences
Male
MicroRNAs - genetics
Non-coding RNA
Prostate - metabolism
Prostate cancer
Prostatic Neoplasms - genetics
Protein kinase
Protein Serine-Threonine Kinases - metabolism
RNA, Long Noncoding - genetics
Transcription factors
Tumorigenesis
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Summary:Long noncoding RNAs (lncRNAs) participate in biological processes in multiple types of tumors. However, the regulatory patterns of lncRNAs in prostate cancer remain largely unclear. Here, we evaluated the expression and roles of the lncRNA DLEU2 in prostate cancer. Our results showed that DLEU2 was upregulated in advanced prostate cancer tissues. Patients with prostate cancer displaying high expression of DLEU2 had a poor prognosis. Moreover, we demonstrated that overexpression of DLEU2 facilitated the proliferation, migration, and invasion of prostate cancer in vitro. Mechanistically, DLEU2 promoted serum and glucocorticoid-induced protein kinase 1 (SGK1) expression by acting as an miR-582-5p sponge, and the transcription of DLEU2 was activated by the dysregulation of E2F transcription factor 2 (E2F2) expression in prostate cancer. Furthermore, knockdown of DLEU2 attenuated prostate cancer tumorigenesis in vivo. Notably, these findings suggested that E2F2-activated DLEU2 may function as a competing endogenous RNA to facilitate prostate cancer progression by targeting the miR-582-5p/SGK1 axis.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-04525-1