Social Cognition in Patients with Early-Onset Parkinson’s Disease

Social cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial em...

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Bibliographic Details
Published in:Parkinson's disease 2021, Vol.2021, p.8852087-13
Main Authors: Seubert-Ravelo, Ana Natalia, Yáñez-Téllez, Ma Guillermina, Lazo-Barriga, María Lizbeth, Calderón Vallejo, Alejandra, Martínez-Cortés, Carlos Eduardo, Hernández-Galván, Adela
Format: Article
Language:English
Subjects:
Age
Batteries
Brain research
Cognition
Cognition & reasoning
Cognitive ability
Decision making
Dementia
Dopamine
Emotions
Medical research
Medicine, Experimental
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Patients
Pattern recognition
Problem solving
Quality of life
Social interactions
Socialization
Statistical analysis
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Summary:Social cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial emotion, theory of mind (ToM), and decision-making domains, with limited research reporting on social reasoning. The main objective of this work was to compare SC ability across four domains: emotional processing, social reasoning, ToM, and decision-making between patients with EOPD and healthy controls. Twenty-five nondemented patients with EOPD and 25 controls matched for sex, age, and educational level were enrolled. A battery that included six SC tests was administered to all study participants; a decision-making scale was completed by participants’ partners. Statistically significant differences were found between patients with EOPD and controls in all subtests across the four SC domains studied. The EOPD group demonstrated worse performance on all tasks, with large effect sizes. Differences remained significant after adjusting for Montreal Cognitive Assessment (MoCA) test scores for all SC subtests except the decision-making scale and the Iowa gambling task. No significant correlations between SC and other clinical PD variables were found. Our study shows that patients with EOPD perform significantly below controls in multiple SC domains affecting recognition of facial emotion, social reasoning, ToM, and decision-making. Only decision-making seems to be mediated by overall cognitive ability. The confounding or contributing effect of other clinical PD variables should be studied further.
ISSN:2090-8083
2042-0080
DOI:10.1155/2021/8852087