A systematic review on the impact of gastrointestinal microbiota composition and function on cognition in healthy infants and children

Evidence from animal models or children with neurodevelopmental disorders has implicated the gut microbiome (GM) in neurocognitive development. However, even subclinical impairement of cognition can have negative consequences, as cognition serves as the foundation for skills necessary to succeed in...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-06, Vol.17, p.1171970-1171970
Main Authors: McMath, Arden L, Aguilar-Lopez, Miriam, Cannavale, Corinne N, Khan, Naiman A, Donovan, Sharon M
Format: Article
Language:English
Subjects:
Animal models
Antibiotics
Attention deficit hyperactivity disorder
Autism
behavior
childhood
Children
Cognition
Cognition & reasoning
Cognitive ability
Cognitive development
Confounding (Statistics)
Data collection
Digestive system
Fatty acids
Feces
Gastrointestinal tract
gut microbiome
infancy
Infants
Intervention
Intestinal microflora
Irritable bowel syndrome
Memory
Microbiomes
Microbiota
Motor skill
Neurodevelopmental disorders
Neuroscience
Systematic review
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Summary:Evidence from animal models or children with neurodevelopmental disorders has implicated the gut microbiome (GM) in neurocognitive development. However, even subclinical impairement of cognition can have negative consequences, as cognition serves as the foundation for skills necessary to succeed in school, vocation and socially. The present study aims to identify gut microbiome characteristics or changes in gut microbiome characteristics that consistently associate with cognitive outcomes in healthy, neurotypical infants and children. Of the 1,520 articles identified in the search, 23 were included in qualitative synthesis after applying exclusion criteria. Most studies were cross-sectional and focused on behavior or motor and language skills. , Clostridia, , and were related to these aspects of cognition across several studies. While these results support the role of GM in cognitive development, higher quality studies focused on more complex cognition are needed to understand the extent to which the GM contributes to cognitive development.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2023.1171970