Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China

Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play in the etiology of ESCC are largely unknown. A mycotoxin biomarker-incorporated,...

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Bibliographic Details
Published in:BMC cancer 2019-12, Vol.19 (1), p.1218-10, Article 1218
Main Authors: Xue, Kathy S, Tang, Lili, Sun, Guiju, Wang, Shaokang, Hu, Xu, Wang, Jia-Sheng
Format: Article
Language:English
Subjects:
Aflatoxin B1
Aflatoxins
Aflatoxins - blood
Aflatoxins - toxicity
Aged
Albumin
Biological markers
Biomarkers
Biomarkers - blood
Biomarkers - urine
Carcinoma
China
Chromatography, High Pressure Liquid
Chronic illnesses
Co-exposure
Creatinine
Developing countries
Dietary Exposure
Epidemiology
Esophageal cancer
Esophageal Neoplasms - chemically induced
Esophageal Neoplasms - epidemiology
Esophageal Squamous Cell Carcinoma - chemically induced
Esophageal Squamous Cell Carcinoma - epidemiology
Esophagus
Etiology
Etiology (Medicine)
Female
Fluorescence
Food consumption
Food Contamination
Food contamination & poisoning
Fumonisin B1
Fumonisins
Fumonisins - toxicity
Fumonisins - urine
High performance liquid chromatography
Humans
Laboratories
LDCs
Lysine
Male
Middle Aged
Molecular epidemiology
Mycotoxins
Population studies
Proteins
Risk Factors
Squamous cell carcinoma
Studies
Urine
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Summary:Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play in the etiology of ESCC are largely unknown. A mycotoxin biomarker-incorporated, population-based case-control study was performed in Huaian area, Jiangsu Province, one of the two high-risk areas in China. Exposure biomarkers of aflatoxins (AF) and fumonisins (FN) were quantitatively analyzed using HPLC-fluorescence techniques. Among the cases (n = 190), the median levels of AF biomarker, serum AFB -lysine adduct, and FN biomarker, urinary FB , were 1.77 pg/mg albumin and 176.13 pg/mg creatinine, respectively. Among the controls (n = 380), the median levels of AFB -lysine adduct and urinary FB were 1.49 pg/mg albumin and 56.92 pg/mg creatinine, respectively. These mycotoxin exposure biomarker levels were significantly higher in cases as compared to controls (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-019-6439-x