Exploring the Effects of Short-Term Daily Intake of Nitraria retusa Tea on Lipid Profile: A Pre-Post, Uncontrolled Pilot Study in Both Healthy and Overweight/Obese Adults

In the present study, we aimed to explore the feasibility, compliance, and potential benefits of Nitraria retusa extract (NRE) intervention in both healthy (BMI ≤ 24.9 Kg/m2) and overweight/obese adults (BMI > 25 Kg/m2). A total of 98 participants, including 37 healthy individuals and 61 overweig...

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Published in:Nutrients 2023-08, Vol.15 (16), p.3649
Main Authors: Laouani, Aicha, Nasrallah, Hana, Sassi, Awatef, Ferdousi, Farhana, Kalai, Feten Zar, Hasni, Yosra, Limem, Khalifa, Isoda, Hiroko, Saguem, Saad
Format: Article
Language:English
Subjects:
Adults
Blood
Body mass index
Cardiovascular disease
Cholesterol
Diabetes
Drug dosages
dyslipidemia
Fatty acids
Flavonoids
HDL
High density lipoprotein
Hypertension
Lipids
Lipoproteins
Liver
Metabolic disorders
Nitraria retusa
Obesity
Overweight
Pilot projects
triglyceride
Womens health
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Summary:In the present study, we aimed to explore the feasibility, compliance, and potential benefits of Nitraria retusa extract (NRE) intervention in both healthy (BMI ≤ 24.9 Kg/m2) and overweight/obese adults (BMI > 25 Kg/m2). A total of 98 participants, including 37 healthy individuals and 61 overweight/obese adults, were randomly assigned to either a low-dose (500 mg/day) or a high-dose (2000 mg/day) NRE intervention group. Plasma lipid biomarkers, liver and kidney functions, general hematology, and blood glucose levels were measured at the baseline and 10 days after intervention. While the lipid profile of the healthy participants did not show any statistically significant changes, the obese participants in the high-dose group experienced a significant decrease in triglyceride levels (within-group difference p value = 0.004) and an increase in HDL levels (within-group p value < 0.001). No significant differences were observed in other parameters, indicating that NRE at the given doses was safe. Furthermore, the study had impressive compliance and acceptability, with over 90% of participants completing the intervention and diligently following the study protocol. This pilot study represents the first investigation into the feasibility, acceptability, and potential benefits of NRE intervention on lipid profiles in human volunteers.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15163649