Substantially Increased Plasma Coproporphyrin‐I Concentrations Associated With OATP1B115 Allele in Japanese General Population

• Published in: Clinical and translational science 2021-01, Vol.14 (1), p.382-388
• Main Authors: Suzuki, Yosuke, Sasamoto, Yuri, Koyama, Teruhide, Yoshijima, Chisato, Nakatochi, Masahiro, Kubo, Michiaki, Momozawa, Yukihide, Uehara, Ritei, Ohno, Keiko
• Format: Article
• Language: English
• Subjects: Biomarkers; Collaboration; Drug dosages; Drug interactions; Equilibrium; Gene polymorphism; Genotype & phenotype; Haplotypes; Kidneys; Laboratories; Organic anion transporting polypeptide; Phenotyping; Plasma; Polymorphism; Polypeptides; Population; Population genetics; Quality control
• ISSN: 1752-8054; 1752-8062
• DOI: 10.1111/cts.12889

Coproporphyrin‐I (CP‐I) in plasma is a sensitive and specific endogenous probe for phenotyping organic anion transporting polypeptides 1B (OATP1B, encoded by SLCO1B). A few small‐scale studies suggested that plasma CP‐I concentration is affected by OATP1B1 polymorphism, but detailed studies are lacking. In this large‐scale study, we measured plasma CP‐I concentrations in 391 subjects from the Japanese general population, and evaluated the relationship between plasma CP‐I concentrations and OATP1B1 polymorphisms to further assess the utility of plasma CP‐I concentrations as an endogenous OATP1B probe. Plasma CP‐I concentrations were 0.45 ± 0.12, 0.47 ± 0.16, 0.47 ± 0.20, 0.50 ± 0.15, 0.54 ± 0.14, and 0.74 ± 0.31 ng/mL in participants with OATP1B1*1b/*1b (n = 103), *1a/*1b (n = 122), *1a/*1a (n = 40), *1b/*15 (n = 74), *1a/*15 (n = 41), and *15/*15 (n = 11), respectively, showing an ascending rank order with significant difference (P