Mitochondrial genotype in vulvar carcinoma - cuckoo in the nest

Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, there is emerging evidence on the use of mtDNA as a diagnostic tool in oncology. In order to...

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Bibliographic Details
Published in:Journal of biomedical science 2010-09, Vol.17 (1), p.73-73, Article 73
Main Authors: Klemba, Aleksandra, Kowalewska, Magdalena, Kukwa, Wojciech, Tonska, Katarzyna, Szybinska, Aleksandra, Mossakowska, Malgorzata, Scinska, Anna, Golik, Paweł, Koper, Kamil, Radziszewski, Jakub, Kukwa, Andrzej, Czarnecka, Anna M, Bartnik, Ewa
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Base Sequence
Cancer
Carcinoma
DNA Mutational Analysis
DNA Primers - genetics
DNA, Mitochondrial - genetics
Female
Genetic aspects
Genetic Predisposition to Disease - genetics
Haplotypes - genetics
Health aspects
Human papillomavirus
Humans
Medical research
Medicine, Experimental
Metabolic disorders
Middle Aged
Mitochondrial DNA
Molecular Sequence Data
Mutation
Mutation - genetics
Ovarian cancer
Papillomavirus infections
Poland
Polymorphism, Restriction Fragment Length
Risk Factors
Vulvar Neoplasms - genetics
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Summary:Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, there is emerging evidence on the use of mtDNA as a diagnostic tool in oncology. In order to investigate mtDNA status in VSCC patients, haplogroup distribution analysis and D-loop sequencing were performed. The results were compared with available data for the general Polish population, cancer free-centenarians as well as patients with endometrial and head and neck cancer. The obtained data were also compared with the current status of mitochondrial databases. Significant differences in haplogroup distribution between VSCC cohort, general Polish population and cancer-free centenarians cohort were found. Moreover, a correlation between the VSCC patients haplogroup and HPV status was observed. Finally, a specific pattern of mtDNA polymorphisms was found in VSCC. Our results suggest that the mitochondrial genetic background may influence the risk of VSCC occurrence as well as susceptibility to HPV infection.
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/1423-0127-17-73