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Manniosides G-J, New Ursane- and Lupane-Type Saponins from Schefflera mannii (Hook.f.) Harms
Four previously unreported triterpenoid saponins named 3β-hydroxy-23-oxours-12-en-28-oic acid 28- -β- -glucopyranosyl ester (mannioside G) ( ), 23- -acetyl-3β-hydroxyurs-12-en-28-oic acid 28- -β- -glucopyranosyl ester (mannioside H) ( ), ursolic acid 28- -[α- -rhamnopyranosyl-(1→4)-β- -glucopyranosy...
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Published in: | Molecules (Basel, Switzerland) Switzerland), 2024-08, Vol.29 (15), p.3447 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Four previously unreported triterpenoid saponins named 3β-hydroxy-23-oxours-12-en-28-oic acid 28-
-β-
-glucopyranosyl ester (mannioside G) (
), 23-
-acetyl-3β-hydroxyurs-12-en-28-oic acid 28-
-β-
-glucopyranosyl ester (mannioside H) (
), ursolic acid 28-
-[α-
-rhamnopyranosyl-(1→4)-β-
-glucopyranosyl-(1→6)-β-
-glucopyranosyl] ester (mannioside I) (
), and 3β-hydroxy-23-oxolup-20(29)-en-28-oic acid 28-
-β-
-glucopyranosyl ester (mannioside J) (
) were isolated as minor constituents from the EtOAc soluble fraction of the MeOH extract of the leaves of
along with the known compounds 23-hydroxyursolic acid 28-
-β-
-glucopyranosyl ester (
), ursolic acid 28-
-β-
-glucopyranosyl ester (
), pulsatimmoside B (
) betulinic acid 28-
-[α-
-rhamnopyranosyl-(1→4)-β-
-glucopyranosyl-(1→6)-β-
-glucopyranosyl] ester (
), 23-hydroxy-3-oxo-urs-12-en-28-oic acid (
), hederagenin (
), ursolic acid (
), betulinic acid (
), and lupeol (
). Their structures were elucidated by a combination of 1D and 2D NMR analysis and mass spectrometry. The MeOH extract, the EtOAc and
-BuOH fractions, and some of the isolated compounds were evaluated for their antibacterial activity against four bacteria:
ATCC1026,
ATCC 35984,
ATCC10536, and
ATCC13882. They were also screened for their antioxidant properties, but no significant results were obtained. |
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ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules29153447 |