Recent advances of miRNAs in the development and clinical application of gastric cancer

Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulat...

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Bibliographic Details
Published in:Chinese medical journal 2020-08, Vol.133 (15), p.1856-1867
Main Authors: Wu, Si-Ran, Wu, Qiong, Shi, Yong-Quan
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers, Tumor
Cell cycle
Cell growth
Chromosomes
Endoscopy
Epidermal growth factor
Gastric cancer
Gene Expression Regulation, Neoplastic
Genes
Humans
Kinases
Ligands
Lymphoma
Metastasis
MicroRNAs
MicroRNAs - genetics
Phosphatase
Prognosis
Proteins
Review
Stomach Neoplasms - genetics
Tumorigenesis
Tumors
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Summary:Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulation of different phenotypes, such as proliferation, apoptosis, invasion and metastasis, drug sensitivity and resistance, and stem-cell-like properties. MiRNAs were evaluated for use in diagnostic and prognostic predictions and exhibited considerable accuracy. Although many problems exist for the application of therapy, current studies showed the antitumor effects of miRNAs. This paper reviews recent advances in miRNA mechanisms in the development of GC and the potential use of miRNAs in the diagnosis and treatment of GC.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000000921