Expanding the Known Functional Repertoire of the Human Cytomegalovirus pp71 Protein

The human cytomegalovirus pp71 protein is packaged within the tegument of infectious virions and performs multiple functions in host cells to prime them for productive, lytic replication. Here we review the known and hypothesized functions of pp71 in regulating proteolysis, infection outcome (lytic...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2020-03, Vol.10, p.95-95
Main Authors: Kalejta, Robert F, Albright, Emily R
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Cellular and Infection Microbiology
chromatin
Cytomegalovirus
HCMV
Humans
Immune Evasion
latency
Nuclear Proteins - metabolism
pp71
tegument
Viral Proteins - genetics
Viral Proteins - metabolism
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Summary:The human cytomegalovirus pp71 protein is packaged within the tegument of infectious virions and performs multiple functions in host cells to prime them for productive, lytic replication. Here we review the known and hypothesized functions of pp71 in regulating proteolysis, infection outcome (lytic or latent), histone deposition, transcription, translation, immune evasion, cell cycle progression, and pathogenesis. We also highlight recent advances in CMV-based vaccine candidates informed by an improved understanding of pp71 function.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2020.00095