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Transcriptomic and metabolomic characterization of antibacterial activity of Melastoma dodecandrum
Antibacterial resistance poses a significant global threat, necessitating the discovery of new therapeutic agents. Plants are a valuable source of secondary metabolites with demonstrated anticancer and antibacterial properties. In this study, we reveal that Melastoma dodecandrum exhibits both bacter...
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Published in: | Frontiers in plant science 2023-09, Vol.14, p.1205725-1205725 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Antibacterial resistance poses a significant global threat, necessitating the discovery of new therapeutic agents. Plants are a valuable source of secondary metabolites with demonstrated anticancer and antibacterial properties. In this study, we reveal that
Melastoma dodecandrum
exhibits both bacteriostatic and bactericidal effects against
Pseudomonas aeruginosa
and
Staphylococcus aureus
. Treatment with plant extracts results in membrane damage and a reduction in
P.aeruginosa
swimming and swarming motility. A comparative analysis of bacterial transcriptomes exposed to M.dodecandrum extracts and four distinct antibiotics indicates that the extracts may trigger similar transcriptomic responses as triclosan, a fatty acid synthesis inhibitor. Activity-guided fractionation suggests that the antibacterial activity is not attributable to hydrolyzable tannins, but to unidentified minor compounds. Additionally, we identified 104 specialized metabolic pathways and demonstrated a high level of transcriptional coordination between these biosynthetic pathways and phytohormones, highlighting potential regulatory mechanisms of antibacterial metabolites in M.dodecandrum. |
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ISSN: | 1664-462X 1664-462X |
DOI: | 10.3389/fpls.2023.1205725 |