What's New in Cryptococcus gattii : From Bench to Bedside and Beyond

species are a major cause of life-threatening infections in immunocompromised and immunocompetent hosts. While most disease is caused by , , a genotypically and phenotypically distinct species, is responsible for 11-33% of global cases of cryptococcosis. Despite best treatment, infections are associ...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2022-12, Vol.9 (1), p.41
Main Authors: Beardsley, Justin, Dao, Aiken, Keighley, Caitlin, Garnham, Katherine, Halliday, Catriona, Chen, Sharon C-A, Sorrell, Tania C
Format: Article
Language:English
Subjects:
Cryptococcosis
Cryptococcus gattii
diagnostic tools
Epidemiology
fungal infection
Genomes
Genotype & phenotype
Infections
medical mycology
Pathogens
Polymorphism
Review
Taxonomy
Virulence
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Summary:species are a major cause of life-threatening infections in immunocompromised and immunocompetent hosts. While most disease is caused by , , a genotypically and phenotypically distinct species, is responsible for 11-33% of global cases of cryptococcosis. Despite best treatment, infections are associated with early mortality rates of 10-25%. The World Health Organization's recently released Fungal Priority Pathogen List classified as a medium-priority pathogen due to the lack of effective therapies and robust clinical and epidemiological data. This narrative review summarizes the latest research on the taxonomy, epidemiology, pathogenesis, laboratory testing, and management of infections.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof9010041