Tissue Engineering in Gynecology

Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (20), p.12319
Main Authors: Brownell, David, Chabaud, Stéphane, Bolduc, Stéphane
Format: Article
Language:English
Subjects:
Biomedical materials
Cell growth
Collagen
Engineers
Female
Fertility
Gynecology
Humans
Hyaluronic acid
Hydrogels
In vitro fertilization
Infertility
Infertility, Female - etiology
Mechanical properties
Menstruation
Ovaries
ovary
Polyethylene glycol
Polyglycolic acid
Polylactic acid
Polymers
Psychological stress
Quality of Life
Recovery of function
Review
Surrogate mothers
Tissue Engineering
Uterus
Uterus - pathology
Vagina
Women
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Summary:Female gynecological organ dysfunction can cause infertility and psychological distress, decreasing the quality of life of affected women. Incidence is constantly increasing due to growing rates of cancer and increase of childbearing age in the developed world. Current treatments are often unable to restore organ function, and occasionally are the cause of female infertility. Alternative treatment options are currently being developed in order to face the inadequacy of current practices. In this review, pathologies and current treatments of gynecological organs (ovaries, uterus, and vagina) are described. State-of-the-art of tissue engineering alternatives to common practices are evaluated with a focus on in vivo models. Tissue engineering is an ever-expanding field, integrating various domains of modern science to create sophisticated tissue substitutes in the hope of repairing or replacing dysfunctional organs using autologous cells. Its application to gynecology has the potential of restoring female fertility and sexual wellbeing.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232012319