Uric acid participating in female reproductive disorders: a review

Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have been explored, and its association with many diseases has been found. The association between...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2021-04, Vol.19 (1), p.65-65, Article 65
Main Authors: Hu, Junhao, Xu, Wenyi, Yang, Haiyan, Mu, Liangshan
Format: Article
Language:English
Subjects:
Animal experimentation
Animal research
Antioxidants
Apoptosis
Cardiovascular disease
Cardiovascular diseases
Development and progression
Endometriosis
Enzymes
Epidemiology
Female reproductive system
Free radicals
Hormones
Inflammation
Kidney diseases
Kinases
Lipids
Medical research
Medicine, Experimental
Metabolism
Metabolites
Mitochondria
Ovaries
Oxidation
Oxidative stress
Physiological aspects
Physiology
Polycystic ovary syndrome
Pregnancy
Pregnancy complications
Proteins
Reproductive system
Review
Risk factors
Stein-Leventhal syndrome
Testosterone
Tumor necrosis factor-TNF
Uric acid
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Summary:Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have been explored, and its association with many diseases has been found. The association between UA and kidney disease and cardiovascular disease is well established; however, there is still a paucity of reviews on the association between UA and the female reproductive system. An increasing number of epidemiological studies have shown elevated serum UA levels in patients with polycystic ovary syndrome (PCOS), endometriosis, etc. Additionally, serum UA can be used as a predictor of pregnancy complications and adverse foetal outcomes. An increasing number of animal experiments and clinical studies have revealed possible mechanisms related to the involvement of UA in certain female reproductive disorders: oxidative stress, chronic inflammation, mitochondrial dysfunction, etc. This article reviews the current mainstream mechanisms regarding the pathogenesis of UA and the role of UA in certain specific female reproductive disorders (direct involvement in the development of certain diseases or enhancement of other risk factors) in the hope of contributing to clinical prevention, diagnosis, treatment and improvement in prognosis.
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-021-00748-7