Effects of leucine supplementation and resistance training on myopathy of diabetic rats

Leucine supplementation and resistance training positively influence the protein translation process and the cell signaling mTOR (mammalian target of rapamycin) pathway that regulates muscle protein balance and muscle remodeling, and thus may be therapeutic to diabetic myopathy. However, the effect...

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Bibliographic Details
Published in:Physiological reports 2017-05, Vol.5 (10), p.e13273-n/a
Main Authors: Martins, Carlos Eduardo C., Lima, Vanessa B. de S., Schoenfeld, Brad J., Tirapegui, Julio
Format: Article
Language:English
Subjects:
Animals
Body Weight
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Dietary Supplements
Drinking
Eating
Endocrine and Metabolic Conditons, Disorders and Treatments
Endurance and Performance
Leucine
Leucine - administration & dosage
leucine supplementation
Male
Motor Control
Motor task performance
Muscle Proteins - metabolism
Muscle, Skeletal - metabolism
Muscular Conditions, Disorders and Treatments
Muscular Diseases - metabolism
Myopathy
Original Research
Physical Conditioning, Animal
Physical training
Physiology
Protein biosynthesis
Protein synthesis
Proteins
Rapamycin
Rats, Wistar
resistance training
Ribosomal Protein S6 Kinases, 70-kDa - metabolism
Rodents
Signalling Pathways
Skeletal Muscle
Strength training
Supplements
TOR protein
TOR Serine-Threonine Kinases - metabolism
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Summary:Leucine supplementation and resistance training positively influence the protein translation process and the cell signaling mTOR (mammalian target of rapamycin) pathway that regulates muscle protein balance and muscle remodeling, and thus may be therapeutic to diabetic myopathy. However, the effect of a combined intervention has not been well studied. Forty male Wistar rats were divided into five groups, control (C), diabetic control (D), diabetic + trained (DT), diabetic + L‐leucine (DL), diabetic + L‐leucine + trained (DLT). The supplementation of 5% leucine in chow, and resistance training were conducted for 8 weeks postweaning of rats. The extensor digitorum longus was used to assess signaling proteins involved in muscle protein synthesis, and the gastrocnemius and soleus were used for determination of muscle weight. Blood samples were collected for biochemical assays. Strength and ambulation tests were employed to evaluate motor performance. Results showed that both leucine supplementation and resistance training elevated the activity of mTOR‐p70S6K in diabetic rats (P 
ISSN:2051-817X
DOI:10.14814/phy2.13273