Adverse drug events and the associated factors in patients with chronic Chagas disease

Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate...

Full description

Saved in:
Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2020-01, Vol.53, p.e20190443-e20190443
Main Authors: Lopes, Luiza Braz da Cunha, Pereira, Raquel Rodrigues, Andrade, Patricia Mello, Carneiro, Fernanda Martins, Mediano, Mauro Felippe Felix, Kilgore, Sophia Isabel Linnemann, Hasslocher-Moreno, Alejandro Marcel, Sousa, Andréa Silvestre de, Oliveira, Manoel Marques Evangelista, Saraiva, Roberto Magalhães, Holanda, Marcelo Teixeira de, Silva, Gilberto Marcelo Sperandio da
Format: Article
Language:English
Subjects:
Adverse drug event
Aged
Algorithms
Brazil - epidemiology
Cardiomyopathy
Chagas disease
Chagas Disease - drug therapy
Chronic Disease
Drug-Related Side Effects and Adverse Reactions - epidemiology
Female
Humans
Male
Middle Aged
Severity of Illness Index
Short Communication
Socioeconomic Factors
TROPICAL MEDICINE
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. Close follow-up is warranted for CD patients.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0443-2019