The Hypnotic Analgesia Suggestion Mitigated the Effect of the Transcranial Direct Current Stimulation on the Descending Pain Modulatory System: A Proof of Concept Study

We evaluated whether active(a)-tDCS combined with hypnotic analgesia suggestion (HS) would be more effective than a single active(a)-tDCS, and/or sham-(s)-tDCS and s-tDCS/HS on the following outcomes: function of descending pain modulatory system (DPMS) during the conditioned pain modulation test (C...

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Bibliographic Details
Published in:Journal of pain research 2020-01, Vol.13, p.2297-2311
Main Authors: Beltran Serrano, Gerardo, Pooch Rodrigues, Laura, Schein, Bruno, Zortea, Maxciel, Torres, Iraci Lucenada Silva, Fregni, Felipe, Caumo, Wolnei
Format: Article
Language:English
Subjects:
Analgesia
Analgesics
Analysis
Brain research
Clinical Trial Report
conditioned pain modulation
Electrodes
Fibromyalgia
Hypnosis
hypnotic analgesia
Intervention
Mental disorders
Methods
Pain
pain perception
Questionnaires
tdcs
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Summary:We evaluated whether active(a)-tDCS combined with hypnotic analgesia suggestion (HS) would be more effective than a single active(a)-tDCS, and/or sham-(s)-tDCS and s-tDCS/HS on the following outcomes: function of descending pain modulatory system (DPMS) during the conditioned pain modulation test (CPM-test) (primary outcome), heat pain threshold (HPT), heat pain tolerance (HPTo) and cold pressor test (CPT) (secondary outcomes). We also examined whether their effects are related to neuroplasticity state evaluated by serum brain-derived-neurotropic factor (BDNF). Forty-eight females received one session of one of the four interventions (a-tDCS/HS, s-tDCS/HS, a-tDCS, and s-tDCS) in an incomplete randomized crossover sequence. The a-tDCS or s-tDCS was applied over the left dorsolateral prefrontal cortex (DLPFC) for 30 minutes at 2mA. A generalized linear model revealed a significant main effect for the intervention group (P
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S253747