Association of serum CTRP9 levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus

Aims Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes and is associated with adipokines. The C1q tumor necrosis factor‐related protein 9 (CTRP9) is a newly discovered adipokine. This study aimed to evaluate the association of serum CTRP9 levels with the prevalence and severit...

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Bibliographic Details
Published in:Journal of diabetes investigation 2021-08, Vol.12 (8), p.1442-1451
Main Authors: Yang, Junpeng, Zhao, Dongni, Chen, Yi, Ma, Yuehua, Shi, Xiaoyang, Wang, Xiaobing, Lv, Yinghua, Yuan, Huijuan
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Aged
Aging
Autonomic nervous system
Autonomic Nervous System Diseases - blood
Autonomic Nervous System Diseases - epidemiology
Biomarkers
Blood Glucose - analysis
Blood pressure
C1q TNF‐related protein 9
Cardiac arrhythmia
Cardiac autonomic neuropathy
Cardiovascular disease
Cholesterol
Cholesterol, HDL - blood
Coronary vessels
Creatinine
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Neuropathies - blood
Diabetic Neuropathies - epidemiology
Diabetic neuropathy
Diabetic retinopathy
Female
Glucose
Glycated Hemoglobin A - analysis
Heart
Heart Diseases - blood
Heart Diseases - epidemiology
Heart rate
Hemoglobin
High density lipoprotein
Humans
Hypertension
Immunoassay
Kidney diseases
Male
Middle Aged
Normal distribution
Original
Patients
Peripheral neuropathy
Prevalence
Regression analysis
Type 2 diabetes
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Summary:Aims Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes and is associated with adipokines. The C1q tumor necrosis factor‐related protein 9 (CTRP9) is a newly discovered adipokine. This study aimed to evaluate the association of serum CTRP9 levels with the prevalence and severity of CAN in patients with type 2 diabetes mellitus. Materials and Methods We enrolled 262 patients (aged ≥18 years) with type 2 diabetes mellitus into this study. Standard cardiovascular autonomic reflex tests (CARTs) were used to assess CAN and patients were divided into three groups accordingly: a non‐CAN group, an early CAN group, and a definite CAN group. Serum CTRP9 levels were measured by enzyme‐linked immunosorbent assay, and the tertiles were calculated. Results Serum CTRP9 levels decreased significantly in the early CAN and definite CAN groups (P 
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.13495