Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering

Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D pri...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2022-05, Vol.27 (11), p.3442
Main Authors: Zhang, Chun-Yang, Fu, Chao-Ping, Li, Xiong-Ya, Lu, Xiao-Chang, Hu, Long-Ge, Kankala, Ranjith Kumar, Wang, Shi-Bin, Chen, Ai-Zheng
Format: Article
Language:English
Subjects:
3-D printers
3D bioprinting
Amino acids
bioink
Biomaterials
Biomedical materials
Biomimetics
Cell adhesion & migration
Cell cycle
Chondroitin sulfate
Collagen
Cytoskeleton
decellularized extracellular matrix
Extracellular matrix
Fibroblasts
Glycoproteins
Hyaluronic acid
Metabolism
Organs
Proteins
Quality control
Review
Signal transduction
Tissue engineering
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cited_by cdi_FETCH-LOGICAL-c423t-6051ff60e5e17b3869d4e11413320618b728ead817740c91832b7753356d45393
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creator Zhang, Chun-Yang
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Chen, Ai-Zheng
description Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D printing to create cell-laden structures. Recently, decellularized extracellular matrix (dECM)-based bioinks derived from natural tissues have garnered enormous attention from researchers due to their unique and complex biochemical properties. This review initially presents the details of the natural ECM and its role in cell growth and metabolism. Further, we briefly emphasize the commonly used decellularization treatment procedures and subsequent evaluations for the quality control of the dECM. In addition, we summarize some of the common bioink preparation strategies, the 3D bioprinting approaches, and the applicability of 3D-printed dECM bioinks to tissue engineering. Finally, we present some of the challenges in this field and the prospects for future development.
doi_str_mv 10.3390/molecules27113442
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subjects 3-D printers
3D bioprinting
Amino acids
bioink
Biomaterials
Biomedical materials
Biomimetics
Cell adhesion & migration
Cell cycle
Chondroitin sulfate
Collagen
Cytoskeleton
decellularized extracellular matrix
Extracellular matrix
Fibroblasts
Glycoproteins
Hyaluronic acid
Metabolism
Organs
Proteins
Quality control
Review
Signal transduction
Tissue engineering
title Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering
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