Impact of Antabuse Treatment on Dyslipidemia and Oxidative Stress Levels in Chronic Alcoholism

• Published in: Journal of stress physiology & biochemistry 2020-12, Vol.16 (4), p.113-118
• Main Authors: Shanmugapriya, V, Karthikeyan, D, Ravish, H, Srinivas, H
• Format: Article
• Language: eng ; rus
• Subjects: Addicts; Alcoholics; Alcoholism; disulfiram; Drug abuse; Dyslipidemia; malondialdehyde; Metabolic disorders; Metabolites; Oxidative stress; Patients; Population studies; Substance abuse treatment
• ISSN: 1997-0838; 1997-0838

Background: Chronic alcoholics are known to have dyslipidemia, which can aggravate organ dysfunction along with increased oxidative stress due to alcohol metabolism. We are studying the impact of Antabuse treatment in reversing the damages caused by chronic alcoholism at metabolite level. Results: This is hospital based cross sectional case control study, with 34 chronic alcoholic patients and 20 Antabuse treated patient for alcoholism. The mean plasma MDA (oxidative stress marker) level among the chronic alcoholics was 12.3 ± 4.3 µmol/L and in Antabuse treated group was 2.8 ± 0.3 µmol/L. Chronic alcoholic group had significantly elevated lipid profile then Antabuse treated group suggesting dyslipidemia in alcoholic group in our study population. Discussion: We observed positive correlation between oxidative stress marker and Lipid profile. Dyslipidemia and oxidative stress levels were significantly lower in Antabuse treated patients suggesting early treatment of such addicts and complete abstinence from consumption showed reversal of the metabolic derangement caused by chronic alcoholism.