Sex Differences and Role of Gonadal Hormones on Glutamate Level, After Spinal Cord Injury in Rats: A Microdialysis Study

Introduction: Sex differences in outcomes of Spinal Cord Injury (SCI) suggest a sex-hormone-mediated effect on post-SCI pathological events, including glutamate excitotoxicity. This study aimed to investigate the importance of gonadal hormones on glutamate release subsequent to SCI in rats.Methods:A...

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Bibliographic Details
Published in:Basic and clinical neuroscience 2019-05, Vol.10 (3), p.225-234
Main Authors: Samandari, Razieh, Hassanpour-Ezatti, Majid, Fakhri, Sajad, Abbaszadeh, Fatemeh, Jorjani, Masoumeh
Format: Article
Language:English
Subjects:
Excitotoxicity
Gender differences
Glutamate
Gonadectomy
Hormones
Microdialysis
Recovery of function
Rodents
Sex differences
Sex hormones
Spinal cord injuries
Spinal Cord Injury
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Summary:Introduction: Sex differences in outcomes of Spinal Cord Injury (SCI) suggest a sex-hormone-mediated effect on post-SCI pathological events, including glutamate excitotoxicity. This study aimed to investigate the importance of gonadal hormones on glutamate release subsequent to SCI in rats.Methods:After laminectomy at T8-T9, an electrolytic lesion was applied to the spinothalamic tracts of male and female rats. Using spinal microdialysis, we assessed glutamate levels at the site of lesion in both intact and gonadectomized rats for 4 hours. In this way, we examined the sex differences in the glutamate concentrations.Results: The peak retention time of glutamate level was 10.6 min and spinal glutamate concentration reached a maximum level 40 min following SCI. In male SCI rats, gonadectomy caused a significant elevation of glutamate level (P
ISSN:2228-7442
2008-126X
2228-7442
DOI:10.32598/bcn.9.10.260