The Role of IL-33 in Host Response to Candida albicans

Background. Interleukin (IL) 33 is a recently identified pleiotropic cytokine that influences the activity of multiple cell types and orchestrates complex innate and adaptive immune responses. Methods. We performed an extensive review of the literature published between 2005 and 2013 on IL-33 and re...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Arenas, R., Sánchez-Blanco, B., Lopez-Bárcenas, A., Rodriguez-Cerdeira, Carmen
Format: Article
Language:English
Subjects:
Animal models
Animals
Candida albicans
Candida albicans - immunology
Candida albicans - pathogenicity
Candidiasis - immunology
Candidiasis - metabolism
Candidiasis - microbiology
Cytokines
Fungal infections
Gene expression
Humans
Immune system
Interleukin-33
Interleukins
Interleukins - metabolism
Kinases
Literature reviews
Mortality
Nosocomial infections
Proteins
Review
Rodents
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Summary:Background. Interleukin (IL) 33 is a recently identified pleiotropic cytokine that influences the activity of multiple cell types and orchestrates complex innate and adaptive immune responses. Methods. We performed an extensive review of the literature published between 2005 and 2013 on IL-33 and related cytokines, their functions, and their regulation of the immune system following Candida albicans colonization. Our literature review included cross-references from retrieved articles and specific data from our own studies. Results. IL-33 (IL-1F11) is a recently identified member of the IL-1 family of cytokines. Accumulating evidence suggests a pivotal role of the IL-33/ST2 axis in host immune defense against fungal pathogens, including C. albicans. IL-33 induces a Th2-type inflammatory response and activates both innate and adaptive immunity. Studies in animal models have shown that Th2 inflammatory responses have a beneficial role in immunity against gastrointestinal and systemic infections by Candida spp. Conclusions. This review summarizes the most important clinical studies and case reports describing the beneficial role of IL-33 in immunity and host defense mechanisms against pathogenic fungi. The finding that the IL-33/ST2 axis is involved in therapeutic target has implications for the prevention and treatment of inflammatory diseases, including acute or chronic candidiasis.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/340690