Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model

Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an impo...

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Published in:Communications biology 2024-03, Vol.7 (1), p.338-338, Article 338
Main Authors: Matsui, Yuichi, Muramatsu, Fumitaka, Nakamura, Hajime, Noda, Yoshimi, Matsumoto, Kinnosuke, Kishima, Haruhiko, Takakura, Nobuyuki
Format: Article
Language:English
Subjects:
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Angiogenesis
Animals
Biomedical and Life Sciences
Brain
Brain - metabolism
Brain Ischemia - metabolism
Cognitive ability
Disease Models, Animal
Endothelial cells
Endothelial Cells - metabolism
Endothelium
Endothelium - metabolism
Inoculation
Ischemia
Ischemic Stroke - metabolism
Lesions
Life Sciences
Mice
Netrin-1
Neuroprotection
Regeneration
Substantia alba
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Summary:Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors. The in vitro coculture of brain cells with ECs from several diverse organs suggested the function of brain-derived endothelium is affected within a brain environment due to netrin-1 and Unc 5B systems. We found brain CD157-positive ECs were more proliferative and beneficial in a mouse model of chronic cerebral hypoperfusion than CD157-negative ECs upon inoculation. We propose novel methods to improve the symptoms of chronic cerebral hypoperfusion using CD157-positive ECs. Brain-derived endothelial cells transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential and were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-024-06030-x