Prevalence and Genetic Diversity of Group A Rotavirus Genotypes in Moscow (2019–2020)

Group A rotavirus (RVA) infection is the leading cause of hospitalization of children under 5 years old, presenting with symptoms of acute gastroenteritis. The aim of our study was to explore the genetic diversity of RVA among patients admitted to Moscow Infectious Disease Clinical Hospital No. 1 wi...

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Bibliographic Details
Published in:Pathogens (Basel) 2021-05, Vol.10 (6), p.674
Main Authors: Yuzhakov, Anton, Yuzhakova, Ksenia, Kulikova, Nadezhda, Kisteneva, Lidia, Cherepushkin, Stanislav, Smetanina, Svetlana, Bazarova, Marina, Syroeshkin, Anton, Grebennikova, Tatiana
Format: Article
Language:English
Subjects:
acute gastroenteritis
Adults
Antigens
DS-1-like
Epidemics
Gastroenteritis
Genes
Genetic diversity
genotype
Genotype & phenotype
Genotypes
Immunization
Infections
Infectious diseases
Mortality
Patient admissions
Polymerase chain reaction
Rotavirus
rotavirus A
Signs and symptoms
Strains (organisms)
Viruses
Wa-like
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Summary:Group A rotavirus (RVA) infection is the leading cause of hospitalization of children under 5 years old, presenting with symptoms of acute gastroenteritis. The aim of our study was to explore the genetic diversity of RVA among patients admitted to Moscow Infectious Disease Clinical Hospital No. 1 with symptoms of acute gastroenteritis. A total of 653 samples were collected from May 2019 through March 2020. Out of them, 135 (20.67%) fecal samples were found to be positive for rotavirus antigen by ELISA. RT-PCR detected rotavirus RNA in 80 samples. Seven G-genotypes (G1, G2, G3, G4, G8, G9, and G12) and three P-genotypes (P[8], P[4], and P[6]) formed 9 different combinations. The most common combination was G9P[8]. However, for the first time in Moscow, the combination G3P[8] took second place. Moreover, all detected viruses of this combination belonged to Equine-like G3P[8] viruses that had never been detected in Russia before. The genotype G8P[8] and G9P[4] rotaviruses were also detected in Moscow for the first time. Among the studied rotaviruses, there were equal proportions of Wa and DS-1-like strains; previous studies showed that Wa-like strains accounted for the largest proportion of rotaviruses in Russia.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens10060674