The correlation between prelabour rupture of the membranes and neonatal infectious diseases, and the evaluation of guideline implementation in China: a multi-centre prospective cohort study

• Published in: The Lancet regional health. Western Pacific 2020-10, Vol.3, p.100029-100029, Article 100029
• Main Authors: Zhuang, Lu, Li, Zhan-Kui, Zhu, Yuan-Fang, Ju, Rong, Hua, Shao-Dong, Yu, Chun-Zhi, Li, Xing, Zhang, Yan-Ping, Li, Lei, Yu, Yan, Zeng, Wen, Cui, Jie, Chen, Xin-Yu, Peng, Jing-Ya, Li, Ting, Feng, Zhi-Chun
• Format: Article
• Language: English
• Subjects: Evaluation; Guideline; Neonatal Infectious Diseases; Prelabour Rupture of Membranes; Research Paper
• ISSN: 2666-6065; 2666-6065
• DOI: 10.1016/j.lanwpc.2020.100029

The aim of this study was to describe the epidemiology of prelabour rupture of membranes (PROM) in China and to assess the association between clinical practice following the guidelines and early neonatal infections. We conducted a prospective cohort study of 15926 deliveries in ShenZhen Baoan Women's and Children's Hospital, Xibei Women's and Children's Hospital and Chengdu Women's and Children's Hospital between August 1, 2017, to March 31, 2018. Clinical data were collected for each participant. The epidemiology of PROM was described. The association between PROM with early neonatal infectious outcomes and the influence of the implementation of the guideline on early neonatal infectious outcomes were assessed. The incidence of PROM was 18•7%. PROM was showed to be a risk factor for neonatal infectious diseases (adjusted OR 1•92, 95%CI 1•49~2•49, p