Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent

Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mut...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.1-18, Article 15943
Main Authors: Doan, Vu Hoang Minh, Nguyen, Van Tu, Mondal, Sudip, Vo, Thi Mai Thien, Ly, Cao Duong, Vu, Dinh Dat, Ataklti, Gebremedhin Yonatan, Park, Sumin, Choi, Jaeyeop, Oh, Junghwan
Format: Article
Language:English
Subjects:
631/45/2783
631/67/1347
639/301/930/2735
Breast cancer
Cancer
Chitosan
Fluorescence
Humanities and Social Sciences
Irradiation
multidisciplinary
Nanocomposites
Nanotechnology
Polypyrroles
Science
Science (multidisciplinary)
Spatial discrimination
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mutually supportive characteristic in terms of spatial resolution, penetration depth, imaging sensitivity, and speed. In this present study, we synthesized IR783 conjugated chitosan–polypyrrole nanocomposites (IR-CS–PPy NCs) as a theragnostic agent used for FL/PA dual-modal imaging. A customized FL and photoacoustic imaging system was constructed to perform required imaging experiments and create high-contrast images. The proposed nanocomposites were confirmed to have great biosafety, essentially a near-infrared (NIR) absorbance property with enhanced photostability. The in vitro photothermal results indicate the high-efficiency MDA-MB-231 breast cancer cell ablation ability of IR-CS–PPy NCs under 808 nm NIR laser irradiation. The in vivo PTT study revealed the complete destruction of the tumor tissues with IR-CS–PPy NCs without further recurrence. The in vitro and in vivo results suggest that the demonstrated nanocomposites, together with the proposed imaging systems could be an effective theragnostic agent for imaging-guided cancer treatment.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-95660-w