GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats

GLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a c...

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Bibliographic Details
Published in:Biomedicines 2023-04, Vol.11 (5), p.1322
Main Authors: Morais, Tiago, Pereira, Sofia S, Andrade, Sara, Neves, Diogo, Guimarães, Marta, Nora, Mário, Carreira, Marcos C, Casanueva, Felipe F, Monteiro, Mariana P
Format: Article
Language:English
Subjects:
adipose tissue
Adipose tissue (brown)
Adipose tissues
Body composition
Body fat
Body weight
Body weight gain
Comparative analysis
Digestive system
Energy
Energy balance
Energy expenditure
Ethylenediaminetetraacetic acid
Explants
Food
Food habits
Food intake
Gastrointestinal tract
Ghrelin
GLP-1
Glucose
Homeostasis
Hormones
Hypothalamus
Insulin resistance
Leptin
Normal distribution
Peptides
Physiological aspects
rat
Statistical analysis
Surgery
Type 2 diabetes
Vagotomy
Vagus nerve
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Summary:GLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a comprehensive evaluation, including eating behavior, body weight, percentage of white (WAT) and brown adipose tissue (BAT), resting energy expenditure (REE) and acute response to GLP-1. Truncal vagotomized rats had significantly lower food intake, body weight, body weight gain, WAT and BAT, with a higher BAT/WAT ratio, but no significant difference in REE when compared to controls. Vagotomized rats also had significantly higher fasting ghrelin and lower glucose and insulin levels. After GLP-1 administration, vagotomized rats depicted a blunted anorexigenic response and higher plasma leptin levels, as compared to controls. However, in vitro stimulation of VAT explants with GLP-1 resulted in no significant changes in leptin secretion. In conclusion, the vagus nerve influences whole-body energy homeostasis by modifying food intake, body weight and body composition and by mediating the GLP-1 anorectic response. The higher leptin levels in response to acute GLP-1 administration observed after truncal vagotomy suggest the existence of a putative GLP-1-leptin axis that relies on the integrity of gut-brain vagal pathway.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11051322